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This product has been discontinued. We recommend 30424-1-AP as an alternative.
For more information, please contact us.


Tested Applications

Positive WB detected inHeLa cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

10946-1-AP targets PEX3 in WB, IF, ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Cited Reactivityhuman, mouse, arabidopsis
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen PEX3 fusion protein Ag1384 相同性解析による交差性が予測される生物種
Full Name peroxisomal biogenesis factor 3
Calculated molecular weight 42 kDa
Observed molecular weight 42 kDa
GenBank accession numberBC014551
Gene Symbol PEX3
Gene ID (NCBI) 8504
RRIDAB_2162392
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDP56589
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. Peroxin 3, also known as PEX3 (peroxisomal biogenesis factor 3) or TRG18, is a 373 amino acid multi-pass membrane protein that anchored in the peroxisomal membrane and essential for peroxisome biogenesis and integrity. Additionally, Peroxin 3 acts as a docking factor for Peroxin 19 and is required for the import of peroxisomal proteins. Defects in the gene encoding Peroxin 3 are the cause of peroxisome biogenesis disorder complementation group 12 (PBD-CG12) and Zellweger syndrome (ZwS), both of which arise from a failure of peroxisomal protein import.

Protocols

Product Specific Protocols
WB protocol for PEX3 antibody 10946-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
mouseWB

Cell Metab

Hif-2α promotes degradation of mammalian peroxisomes by selective autophagy.

Authors - Katharina M Walter
humanWB

Cell Death Differ

Peroxisome-driven ether-linked phospholipids biosynthesis is essential for ferroptosis.

Authors - Weiwei Cui
mouseWB

Kidney360

Pkd1 Mutation Has No Apparent Effects on Peroxisome Structure or Lipid Metabolism.

Authors - Takeshi Terabayashi
mouseWB

Methods Mol Biol

Isolation of Peroxisomes from Mouse Brain Using a Continuous Nycodenz Gradient: A Comparison to the Isolation of Liver and Kidney Peroxisomes.

Authors - Miriam J Schönenberger
mouseWB

Biochim Biophys Acta

Peroxisome deficiency-induced ER stress and SREBP-2 pathway activation in the liver of newborn PEX2 knock-out mice.

Authors - Kovacs Werner J WJ
ArabidopsisWB

J Integr Plant Biol

PEX16 contributions to peroxisome import and metabolism revealed by viable Arabidopsis pex16 mutants.

Authors - Sarah E Burkhart
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