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Validation Data Gallery

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  • Immunohistochemistry (IHC) staining of mouse skeletal muscle tissue using PERM1 Recombinant antibody (84425-5-RR)

    IHC staining of mouse skeletal muscle using 84425-5-RR (same clone as 84425-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 84425-5-RR (PERM1 antibody) at dilution of 1:500 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84425-5-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of mouse skeletal muscle tissue using PERM1 Recombinant antibody (84425-5-RR)

    IHC staining of mouse skeletal muscle using 84425-5-RR (same clone as 84425-5-PBS)

    Immunohistochemical analysis of paraffin-embedded mouse skeletal muscle tissue slide using 84425-5-RR (PERM1 antibody) at dilution of 1:500 (under 20x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 84425-5-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of H9C2 cells using PERM1 Recombinant antibody (84425-5-RR)

    IF Staining of H9C2 using 84425-5-RR (same clone as 84425-5-PBS)

    Immunofluorescent analysis of (4% PFA) fixed H9C2 cells using PERM1 antibody (84425-5-RR, Clone: 241613B6 ) at dilution of 1:250 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2), CL594-Phalloidin (red). This data was developed using the same antibody clone with 84425-5-PBS in a different storage buffer formulation.

  • Affinity and Kinetic Characterization of 84425-5-RR

    Affinity and Kinetic Characterization of 84425-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84425-5-RR against Human PERM1 were performed. The affinity constant is below 1 pM.

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PERM1 Recombinant antibody, PBS Only

PERM1 Uni-rAbTM Recombinant Antibody for IHC, IF/ICC, Indirect ELISA
Cat No. 84425-5-PBS
Clone No.241613B6

Host / Isotype

Rabbit / IgG

Reactivity

human, rat

Applications

IHC, IF/ICC, Indirect ELISA

Synonyms

C1orf170, PERM, 241613B6

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

84425-5-PBS targets PERM1 in IHC, IF/ICC, Indirect ELISA applications and shows reactivity with human, rat samples.

Tested Reactivity human, rat
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen PERM1 fusion protein Ag23833 相同性解析による交差性が予測される生物種
Full Name chromosome 1 open reading frame 170
GenBank accession numberBC006300
Gene Symbol C1orf170
Gene ID (NCBI) 84808
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDQ5SV97
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

PERM1 (PGC-1/ERR-induced regulator in muscle 1) is a muscle-specific protein induced by PGC-1α and ERRα. PERM1 protein expression is mainly restricted to heart and skeletal muscle, indicating PERM1 functions as a tissue-specific regulator of mitochondrial biogenesis in response to exercise (PMID: 33549681, 36028747). Ablation of Perm1 in mice results in reduced protein expression of lipin-1 accompanied by accumulation of specific phospholipid species (PMID: 33549681). There are two major isoforms of Perm1 protein, the short isoform is about 85 kDa, and the long isoform is 105 kDa.