Validation Data Gallery
69512-1-Ig
Product Information
69512-1-PBS targets TGF beta 1 in applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | human Humankine TGF beta 1 protein HZ-1011 相同性解析による交差性が予測される生物種 |
| Full Name | transforming growth factor, beta 1 |
| Calculated molecular weight | 44 kDa |
| Gene Symbol | TGFB1 |
| Gene ID (NCBI) | 7040 |
| Conjugate | Unconjugated |
| Form | Lyophilized Powder |
| Purification Method | Protein A purification |
| Storage Buffer | PBS Only , pH 7.4 |
| Endotoxin | <0.1 EU/μg |
| Reconstitution | This product was lyophilized from a 0.2 μm filtered solution in PBS. Reconstitute at 1.0 mg/mL in sterile H2O before use. |
| Stability and Storage | Lyophilized antibodies are stable for 1 year from the date of receipt if stored between (-20°C) and (-80°C). Upon reconstitution we recommend that the solution can be stored at (4°C) for short term or at (-20°C) to (-80°C) for long term. Repeated freeze thaw cycles should be avoided with reconstituted products. |
Background Information
TGFB, also named as LAP and TGFB1, is a multifunctional peptide that controls proliferation, differentiation, and other functions in many cell types. TGFB acts synergistically with TGFA in inducing transformation. It also acts as a negative autocrine growth factor. Dysregulation of TGFB activation and signaling may result in apoptosis. Many cells synthesize TGFB and almost all of them have specific receptors for it. TGFB positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. It is highly expressed in bone. Mutation of TGFB are the cause of Camurati-Engelmann disease (CED) which known as progressive diaphyseal dysplasia 1 (DPD1).
This antibody is a neutralizing control antibody for TGF beta 1, the immunogen is the same as Neutrakine 69012-1-Ig but could not neutralize human TGF beta 1.