Validation Data Gallery
69527-1-Ig
Product Information
69527-1-PBS targets HGF in applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen |
Recombinant Protein 相同性解析による交差性が予測される生物種 |
| Full Name | hepatocyte growth factor (hepapoietin A; scatter factor) |
| Gene Symbol | HGF |
| Gene ID (NCBI) | 3082 |
| Conjugate | Unconjugated |
| Form | |
| Purification Method | Protein A purification |
| UNIPROT ID | P14210 |
| Storage Buffer | PBS Only{{ptg:BufferTemp}}7.4 |
| Storage Conditions | Store at -80°C. |
Background Information
Hepatocyte growth factor (HGF) is the most potent mitogen of mature hepatocytes in primary culture. HGF is derived from a biologically inactive single chain precursor of 728 amino acids (pro-HGF) localized mostly on the cell surface and in the extracellular matrix. The mature form produced following proteolytic cleavage is composed of a 69-kDa α-subunit (containing four kringle domains) and the 34 kDa β-subunit, similar to the catalytic domain of serine proteases, but with amino acid substitutions in the active site. HGF is a pleiotropic cytokine which exerts a variety of effects on several cells, being involved in the regulation of many biological processes, such as inflammation, tissue repair, morphogenesis, angiogenesis, tumour propagation, immunomodulation of viral infections and cardio-metabolic activities.
This antibody is a neutralizing control antibody for HGF, the immunogen is the same as Neutrakine 69027-1-Ig but could not neutralize human HGF.