Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
13275-1-PBS targets NXF3 in WB, IHC, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag3998 Product name: Recombinant human NXF3 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 1-303 aa of BC031616 Sequence: MSLPSGHTTGHTDQVVQRRARCWDIYQRRFSSRSEPVNPGMHSSSHQQQDGDAAMHGAHMDSPVRYTPYTISPYNRKGSFRKQDQTHVNMEREQKPPERRMEGNMPDGTLGSWFKITVPFGIKYNEKWLLNLIQNECSVPFVPVEFHYENMHASFFVENASIAYALKNVSGKIWDEDNEKISIFVNPAGIPHFVHRELKSEKVEQIKLAMNQQCDVSQEALDIQRLPFYPDMVNRDTKMASNPRKCMAASLDVHEENIPTVMSAGEMDKWKGIEPGEKCADRSPVCTTFSDTSSNINSILELF 相同性解析による交差性が予測される生物種 |
| Full Name | nuclear RNA export factor 3 |
| Calculated molecular weight | 531 aa, 60 kDa |
| GenBank accession number | BC031616 |
| Gene Symbol | NXF3 |
| Gene ID (NCBI) | 56000 |
| RRID | AB_2877933 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9H4D5 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
NXF3 (nuclear RNA export factor 3) belongs to the NXF family of RNA transport proteins, predominantly expressed in human testis cells. Unlike canonical NXF1, it bears truncated functional domains and lacks typical RNA-binding capacity. It mediates nucleocytoplasmic shuttling of snoRNAs and regulates TGF-β3 mRNA trafficking independent of bulk mRNA export. Recent studies confirm its oncogenic role in gastric cancer, where elevated NXF3 accelerates tumor proliferation, invasion and predicts poor patient survival. It acts as a prognostic biomarker and a potential therapeutic target for gastrointestinal malignancies. (PMID: 29021253)


