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Validation Data Gallery

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  • Western Blot (WB) analysis of A549 cells using NLRP2 Polyclonal antibody (15182-1-AP)

    WB analysis of A549 using 15182-1-AP (same clone as 15182-1-PBS)

    A549 cells were subjected to SDS PAGE followed by western blot with 15182-1-AP (NLRP2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15182-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of A549 cells using NLRP2 Polyclonal antibody (15182-1-AP)

    WB analysis of A549 using 15182-1-AP (same clone as 15182-1-PBS)

    A549 cells were subjected to SDS PAGE followed by western blot with 15182-1-AP (NLRP2 antibody) at dilution of 1:1500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15182-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of human lung tissue using NLRP2 Polyclonal antibody (15182-1-AP)

    WB analysis of human lung using 15182-1-AP (same clone as 15182-1-PBS)

    human lung tissue were subjected to SDS PAGE followed by western blot with 15182-1-AP (NLRP2 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 15182-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of A549 cells using NLRP2 Polyclonal antibody (15182-1-AP)

    IP experiment of A549 using 15182-1-AP (same clone as 15182-1-PBS)

    IP result of anti-NLRP2 (IP:15182-1-AP, 4ug; Detection:15182-1-AP 1:3000) with A549 cells lysate 920 ug. This data was developed using the same antibody clone with 15182-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human placenta tissue using NLRP2 Polyclonal antibody (15182-1-AP)

    IHC staining of human placenta using 15182-1-AP (same clone as 15182-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 15182-1-AP (NLRP2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15182-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human placenta tissue using NLRP2 Polyclonal antibody (15182-1-AP)

    IHC staining of human placenta using 15182-1-AP (same clone as 15182-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human placenta tissue slide using 15182-1-AP (NLRP2 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 15182-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

NLRP2 Polyclonal antibody, PBS Only

NLRP2 Polyclonal Antibody for WB, IHC, IP, Indirect ELISA
Cat No. 15182-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IP, Indirect ELISA

Synonyms

CLR19.9, NACHT, LRR and PYD domains-containing protein 2, NALP2, NBS1, Nucleotide-binding site protein 1

Formulation:  PBS Only
PBS, Azide, Glycerol
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

15182-1-PBS targets NLRP2 in WB, IHC, IP, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag7167

Product name: Recombinant human NLRP2 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 1-350 aa of BC001039

Sequence: MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILTTHCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDVDEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSKEVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLIHKFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGAAPGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEE

相同性解析による交差性が予測される生物種
Full Name NLR family, pyrin domain containing 2
Calculated molecular weight 121 kDa
Observed molecular weight 105-110 kDa
GenBank accession numberBC001039
Gene Symbol NLRP2
Gene ID (NCBI) 55655
RRIDAB_2298531
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9NX02
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

NLRP2 (NLR family pyrin domain containing 2) is a member of the Nod-like receptor (NLR) family, characterized by an N-terminal pyrin domain (PYD), a central NACHT domain, and C-terminal leucine-rich repeats (LRRs). Encoded on chromosome 19q13.42, NLRP2 is widely expressed across tissues, with particularly high levels in the placenta, lung, thymus, and notably in oocytes and early embryos. Functionally, NLRP2 has emerged as a pleiotropic regulator with seemingly context-dependent roles. It can modulate innate immune signaling by inhibiting NF-κB activation and interacting with components of the IKK complex, while also promoting caspase-1 activation and IL-1β secretion, suggesting a role in inflammasome assembly. Beyond immunity, NLRP2 is essential for female reproduction, functioning as a non-core component of the subcortical maternal complex (SCMC) critical for preimplantation embryonic development; its deficiency or mutation is associated with female infertility and embryonic developmental arrest. Although historically less studied than NLRP1 or NLRP3, emerging evidence implicates NLRP2 in diverse pathological contexts, including neuroinflammation, ischemic stroke, and kidney damage, underscoring its potential as a therapeutic target.

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