MultiProTM-5CFLX Anti-Human SYK (4C4A12)
SYK Monoclonal Antibody for
Host / Isotype
Mouse / IgG2b
Reactivity
Human
Applications
Conjugate
5CFLX Fluorescent Dye
CloneNo.
4C4A12
Cat no : G66721-1-5C
Synonyms
Validation Data Gallery
Tested Applications
| Positive Single Cell (Intra) detected in | 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing product |
Recommended dilution
| Application | Dilution |
|---|---|
| SINGLE CELL (INTRA) | SINGLE CELL (INTRA) : <0.5ug/test |
| Sample-dependent, check data in validation data gallery | |
Product Information
G66721-1-5C targets SYK in applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | SYK fusion protein Ag17654 相同性解析による交差性が予測される生物種 |
| Full Name | spleen tyrosine kinase |
| Calculated molecular weight | 635 aa, 72 kDa |
| GenBank accession number | BC001645 |
| Gene symbol | SYK |
| Gene ID (NCBI) | 6850 |
| Conjugate | 5CFLX Fluorescent Dye |
| Form | Liquid |
| Purification Method | |
| Storage Buffer | PBS with 1mM EDTA and 0.09% sodium azide |
| Storage Conditions | 2-8°C |
Background Information
SYK(spleen tyrosine kinase) is a key regulator of signal transduction events,apoptosis and orderly cell cycle progression in B-lineage lymphoid cells. Although SYK has not been linked to a human disease, defective expression of the closely related T-cell tyrosine kinase ZAP-70 has been associated with severe combined immunodeficiency(PMID:11494125). This protein has 2 isoforms produced by alternative splicing. SYK also promotes liver fibrosis by activation of hepatic stellate cells and acts as a biomarker for human hepatocellular carcinoma. (PMID: 29537660)
