MultiProTM-5CFLX Anti-Human MFN2 (5F3B3)
MFN2 Monoclonal Antibody for
Host / Isotype
Mouse / IgG2a
Reactivity
Human
Applications
Conjugate
5CFLX Fluorescent Dye
CloneNo.
5F3B3
Cat no : G67487-1-5C
Synonyms
Validation Data Gallery
Tested Applications
| Positive Single Cell (Intra) detected in | 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing product |
Recommended dilution
| Application | Dilution |
|---|---|
| SINGLE CELL (INTRA) | SINGLE CELL (INTRA) : <0.5ug/test |
| Sample-dependent, check data in validation data gallery | |
Product Information
G67487-1-5C targets MFN2 in applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Immunogen | MFN2 fusion protein Ag29873 相同性解析による交差性が予測される生物種 |
| Full Name | mitofusin 2 |
| Calculated molecular weight | 757 aa, 86 kDa |
| GenBank accession number | BC017061 |
| Gene symbol | MFN2 |
| Gene ID (NCBI) | 9927 |
| Conjugate | 5CFLX Fluorescent Dye |
| Form | Liquid |
| Purification Method | |
| Storage Buffer | PBS with 1mM EDTA and 0.09% sodium azide |
| Storage Conditions | 2-8°C |
Background Information
MFN2, also named as CPRP1 and KIAA0214, belongs to the mitofusin family. It is an Essential transmembrane GTPase, which mediates mitochondrial fusion. MFN2 acts independently of the cytoskeleton. It therefore plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes. Overexpression of MFN2 induces the formation of mitochondrial networks. It plays an important role in the regulation of vascular smooth muscle cell proliferation. Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 2A2 (CMT2A2). Defects in MFN2 are the cause of Charcot-Marie-Tooth disease type 6 (CMT6). Ubiquitinated forms of Mfn2 (mono- and polyubiquitinated) are present during mitophagy.
