MultiProTM-5CFLX Anti-Human MAFB (Polyclonal)
MAFB Polyclonal Antibody for
Host / Isotype
Rabbit / IgG
Reactivity
Human
Applications
Conjugate
5CFLX Fluorescent Dye
Cat no : G20189-1-5C
Synonyms
Validation Data Gallery
Tested Applications
| Positive Single Cell (Intra) detected in | 10x Genomics Gene Expression Flex with Feature Barcodes and Multiplexing product |
Recommended dilution
| Application | Dilution |
|---|---|
| SINGLE CELL (INTRA) | SINGLE CELL (INTRA) : <0.5ug/test |
| Sample-dependent, check data in validation data gallery | |
Product Information
G20189-1-5C targets MAFB in applications and shows reactivity with Human samples.
| Tested Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | MAFB fusion protein Ag14102 相同性解析による交差性が予測される生物種 |
| Full Name | v-maf musculoaponeurotic fibrosarcoma oncogene homolog B (avian) |
| Calculated molecular weight | 323 aa, 36 kDa |
| GenBank accession number | BC036689 |
| Gene symbol | MAFB |
| Gene ID (NCBI) | 9935 |
| Conjugate | 5CFLX Fluorescent Dye |
| Form | Liquid |
| Purification Method | |
| Storage Buffer | PBS with 1mM EDTA and 0.09% sodium azide |
| Storage Conditions | 2-8°C |
Background Information
MAFB (MAF BZIP Transcription Factor B), also known as V-maf musculoaponeurotic fibrosarcoma oncogene homolog B, is a widely expressed basic leucine zipper transcription factor belonging to the Maf family. MAFB expression is significantly elevated in response to a broad range of metabolic and immunological stimuli that promote macrophage M2 polarization, cholesterol efflux, or both, whereas it is strongly down-regulated in response to various pro-inflammatory pathogenic triggers(PMID: 28790455). MAFB is highly expressed in tumor tissues and required for proliferation and tumorigenicity of osteosarcoma cells(PMID: 32234710) and is a marker of tumor-associated macrophages in both mouse and human(PMID: 31679694).
