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Host
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Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
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Compatible Species
0
Conjugate
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Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Purchase

Recombinant Mouse OLR1/LOX1 protein (rFc Tag) (HPLC verified)

Species

Mouse

Purity

>90 %, SDS-PAGE
>90 %, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg2473

Validation Data Gallery

  • Purity of Recombinant Mouse OLR1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse OLR1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Mouse OLR1 was greater than 90% as determined by SEC-HPLC.

    The purity of Mouse OLR1 was greater than 90% as determined by SEC-HPLC.

Product Information

Purity >90 %, SDS-PAGE
>90 %, SEC-HPLC
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Mouse OLR1 protein Arg60-Ile363 (Accession# Q9EQ09) with a rabbit IgG Fc tag at the C-terminus.
GeneID 108078
Accession Q9EQ09
PredictedSize 61.0 kDa
SDS-PAGE 65-85 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

OLR1 (also known as LOX1) is the receptor of oxidized low-density lipoprotein (ox-LDL) and is mainly expressed in endothelial cells, macrophages, smooth muscle cells, platelets, fibroblasts, and neurons. OLR1 is almost undetectable under physiological conditions, but it is upregulated following exposure to several proinflammatory and proatherogenic stimuli and can be detected in animal and human atherosclerotic lesions. OLR1 is the major contributor to ox-LDL uptake, internalization, and degradation in various cells. OLR1 plays a role in metabolism, cardiovascular disease and cancer.

References:

1.Pirillo A. et al. (2013) Mediators Inflamm. 2013:152786.
2.Jin P and Cong S. (2019) Clin Chim Acta. 491:24-29.
3.Zhang P.  et al. (2023) Oncoimmunology. 12(1):2203073. 
4.Wu L. et al. (2023) Int J Mol Sci. 24(16):12904.