Recombinant Mouse NGFR/TNFRSF16 protein (mFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
mFc Tag
Activity
not tested
Cat no : Eg3867
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse p75NTR protein Lys32-Asp252 (Accession# Q9Z0W1-1) with a mouse IgG Fc tag at the C-terminus. |
| GeneID | 18053 |
| Accession | Q9Z0W1-1 |
| PredictedSize | 50.1 kDa |
| SDS-PAGE | 60-80 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
NGFR, also named as TNFRSF16, Gp80-LNGFR, p75 ICD and CD271, a member of the tumor necrosis factor superfamily. It is highly expressed in both neurons and glial cells during CNS development and after brain injury, whereas in normal adulthood, it is present only in specific brain regions such as neurons and astrocytes of hippocampal and especially in the cholinergic neurons of the basal forebrain. NGFR can mediate cell survival or cell death, can promote or inhibit axonal growth, and can facilitate or attenuate proliferation, depending on the cell context.
References:
1.Cragnolini, Andrea B, and Wilma J Friedman. Trends in neurosciences vol. 31,2 (2008): 99-104. 2.Chen, Mingming et al. Cellular and molecular neurobiology vol. 42,4 (2022): 1153-1166. 3.Yang, Chun-Rui et al. FASEB journal vol. 36,3 (2022): e22180. 4.Ali, Naif H et al. Molecular neurobiology vol. 61,5 (2024): 2469-2480. 5.Xie, Bo et al. Frontiers in cell and developmental biology vol. 11 (2023): 1283878.