Recombinant Mouse NKG2C/CD159c protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg1505
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse NKG2C protein Ser89-Ile238 (Accession# Q9WTJ9) with a rabbit IgG Fc tag at the N-terminus. |
| GeneID | 16642 |
| Accession | Q9WTJ9 |
| PredictedSize | 44.2 kDa |
| SDS-PAGE | 48-68 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
NKG2-C type II integral membrane protein (NKG2C) is also named CD159c. NKG2C regulates the effector functions of terminally differentiated cytotoxic lymphocyte subsets, and in particular may play a role in adaptive NK cell response to viral infection (PMID:20952657, PMID:21825173). Upon HLA-E-peptide binding, NKG2C transmits intracellular signals via the adapter protein TYROBP/DAP12, triggering the phosphorylation of proximal signaling molecules and cell activation (PMID:15940674, PMID:9655483).
References:
1.Angelini DF, et al. (2011) J Leukoc Biol. 89(1):75-84. 2.Lopez-Vergès S, et al. (2011) Proc Natl Acad Sci U S A. 108(36):14725-32. 3.Gumá M, et al. (et al) Eur J Immunol. 35(7):2071-80. 4.Lanier LL, et al. (1998) Immunity. 8(6):693-701.