Recombinant Mouse LTBR/TNFRSF3 protein (C-rFc)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg6278
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse LTBR protein Gln31-Leu223 (Accession# P50284) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 17000 |
| Accession | P50284 |
| PredictedSize | 47.3 kDa |
| SDS-PAGE | 53-65 kDa , reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Lymphotoxin-beta receptor (LTBR) is also named TNFRSF3 and Tumor necrosis factor receptor type III (TNF-RIII; TNFR-III). LTBR is a receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It can activate the NF-kappa-B signaling pathway upon stimulation with lymphotoxin (LTA1-LTB2). LTBR is constitutively expressed on stromal cells and myeloid lineage cells but not on T or B lymphocytes, which may be a novel immune checkpoint of tumor-associated macrophages.
References:
1.Sudhamsu, Jawahar et al. Proceedings of the National Academy of Sciences of the United States of America vol. 110,49 (2013): 19896-901. 2.Wolf, M J et al. Oncogene vol. 29,36 (2010): 5006-18. 3.Wang, Liang et al. iMeta vol. 3,5 e233. 4 Sep. 2024