Recombinant Mouse IL-20 protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg2797
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse IL-20 protein Leu25-Leu176 (Accession# Q9JKV9) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 58181 |
| Accession | Q9JKV9 |
| PredictedSize | 43.6 kDa |
| SDS-PAGE | 39-48 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
As a member of the IL-10 family, IL-20 functions as a proinflammatory cytokine by binding to its complex receptors (IL-20R1/IL-20R2 and IL-20R2/IL-22R1) on target cells. Excessive IL-20 expression is associated with chronic inflammatory diseases, such as rheumatoid arthritis and osteoporosis.
References:
1. Wang HH. et al. (2022). J Biomed Sci. 29(1):36. 2. Hsu YH. et al. (2011). J Exp Med. 208(9):1849–1861. 3. Hsu YH. et al. (2017). Drug Discov Today. 22(6):960–964.