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Recombinant Mouse Dectin-1 protein (rFc Tag)(HPLC verified)

Species

Mouse

Purity

>90 %, SDS-PAGE
>90%, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg2676

Validation Data Gallery

  • Purity of Recombinant Mouse Dectin-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Mouse Dectin-1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
>90%, SEC-HPLC
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Mouse Dectin-1 protein Gly71-Leu244 (Accession# Q6QLQ4) with a rabbit IgG Fc tag at the C-terminus.
GeneID 56644
Accession Q6QLQ4
PredictedSize 45.8 kDa
SDS-PAGE 48-60 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

C-type lectin structural domain family 7 member A (Clec7a), also known as Dectin-1, is a transmembrane protein containing an intracellular immune receptor tyrosine-based activation (ITAM)-like motif and an extracellular C-type lectin-like structural domain for recognition. Clec7a has important roles in the innate immune system, particularly in the recognition of β-glucans. Studies have revealed potential links between Clec7a and a variety of biological processes such as immune homeostasis, autoimmunity, allergy, and cancer. Clec7a regulates phagocytosis by macrophages in a variety of peripheral tissues. Clec7a is upregulated in microglial cells during neurodegeneration and is an important receptor for microglial cell activation in response to AD pathology. (PMID: 39088351)

References:

1. Wan H, et al. (2024). Adv Sci (Weinh). 11(36):e2403064.                                          
2. Wang J, et al. (2024). Front Immunol. 15:1361351.                                                                                                                            3. Wang Y, et al. (2022). Front Immunol. 13:1008727.
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