Recombinant Mouse CD5L protein (rFc Tag) (HPLC verified)
Species
Mouse
Purity
>90 %, SDS-PAGE
>90 %, SEC-HPLC
Tag
rFc Tag
Activity
not tested
Cat no : Eg2786
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE >90 %, SEC-HPLC |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse CD5L protein Glu22-Val352 (Accession# Q9QWK4) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 11801 |
| Accession | Q9QWK4 |
| PredictedSize | 62.6 kDa |
| SDS-PAGE | 70-85 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
CD5-like (CD5L) is a 40-kDa soluble glycoprotein that belongs to the SRCR superfamily. CD5L is secreted primarily from macrophages in lymphoid tissues during inflammatory response.CD5L modulates the activity of macrophages in a wide spectrum of settings, including the pathogenesis of several infectious and inflammatory processes. CD5L plays important roles in many diseases, such as metabolic syndrome, acute kidney injury as well as cardiac rejection.
References:
1.Sanjurjo L. et al. (2018) Front Immunol. 9:480. 2.Sanchez-Moral L. et al. (2023) EBioMedicine. 91:104555. 3.LaFargue CJ. et al. (2023) Nat Commun. 14(1):2407. 4.Oskam N. et al. (2023) Proc Natl Acad Sci U S A. 120(50):e2311265120. 5.Yang H. et al. (2024) Autoimmunity. 57(1):2201412.