Recombinant Mouse CD222/Igf2r protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg6300
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse CD222 protein Gln36-Ala2295 (Accession# Q07113) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 16004 |
| Accession | Q07113 |
| PredictedSize | 275.1 kDa |
| SDS-PAGE | 240-350 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in 500 mM Arg, 30 mM Tris, pH8.0. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
IGF2R, also named as CD222, CI Man-6-P receptor, CI-MPR, M6PR, IGF-II receptor, M6P/IGF2R, MPR 300 and MPRI, and belongs to the MRL1/IGF2R family.The insulin-like growth factor receptor type 2 (IGF2R) sequesters the insulin-like growth factor (IGF-II) for internalization and degradation and also is considered a tumor suppressor with mutations being found in several cancers. Unusually high levels of circulating IGF-II and simultaneous downregulation of IGF2R are correlated with the growth of human and murine tumors while loss of function of IGF2R resulting in increased growth.
References:
1. Falls J.G., et al. Am. J. Pathol. 1999;154:635–647. 2.Toretsky J.A., et al. J. Endocrinol. 1996;149:367–372. 3. Hassan A.B., et al. Cancer Res. 2000;60:1070–1076. 4. Foulstone E., et al. J. Pathol. 2005;205:145–153.