Recombinant Mouse CD268/BAFF-R protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg1840
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse CD268 protein Ser10-Ala71 (Accession# Q9D8D0-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 72049 |
| Accession | Q9D8D0-1 |
| PredictedSize | 33.0 kDa |
| SDS-PAGE | 37-50 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
B-cell-activating factor receptor (BAFF-R, also known as CD268 and TNFRSF13C) is a member of the tumor necrosis factor receptor (TNFR) superfamily. It is expressed in most malignant B cells, including those in primary central nervous system lymphoma (PCNSL), and is involved in the survival and proliferation of these cells. The interaction of BAFF with BAFF-R promotes NF-κB activation, which plays a crucial role in B-cell maturation, survival, and costimulation of T-cell activation and proliferation. Additionally, BAFF-R is associated with chronic kidney disease (CKD) by activating NF-κB signaling in renal tubular epithelial cells.
References:
1. Zhou, Xiaolan et al. Frontiers in oncology vol. 10 682. 27 May (2020). 2. Smulski, Cristian R, and Hermann Eibel. Frontiers in immunology vol. 9 2285. 8 Oct (2018). 3. Möckel, Tamara et al. International journal of molecular sciences vol. 25,10 5415. 16 May (2024).