Recombinant Mouse Atp1b1 protein (rFc Tag)
Species
Mouse
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg3007
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Mouse Atp1b1 protein Glu63-Ser304 (Accession# P14094) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 11931 |
| Accession | P14094 |
| PredictedSize | 53.7 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
ATP1B1 is one of beta subunits of the Na+/K+ ATPase and responsible for formation and structural integrity of the Na+/K+ ATPase, which is a plasma membrane pump consisting of alpha, beta, and gamma subunits. ATP1B1 plays an important role in maintaining the normal gradients of Na+ and K+ across plasma membrane. ATP1B1 also plays an active role during the pathogenesis of leukemia and overexpression of ATP1B1 may also predict a poor prognosis in CN‑AML patients. ATP1B1 is a useful biomarker for the clinical diagnosis and prognosis of DLBCL
References:
1. Xiao, Bing et al. Clinica chimica acta; international journal of clinical chemistry vol. 407,1-2 (2009): 47-50. 2. Shi, Jin-long et al. Oncotarget vol. 7,3 (2016): 2585-95. 3. Zhang, Shuo et al. Annals of translational medicine vol. 10,20 (2022): 1136.