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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using MVK Monoclonal antibody (67820-1-Ig)

    WB analysis using 67820-1-Ig (same clone as 67820-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 67820-1-Ig (MVK antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67820-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of U2OS cells using MVK Monoclonal antibody (67820-1-Ig)

    WB analysis of U2OS using 67820-1-Ig (same clone as 67820-1-PBS)

    U2OS cells were subjected to SDS PAGE followed by western blot with 67820-1-Ig (MVK antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 67820-1-PBS in a different storage buffer formulation.

MVK Monoclonal antibody, PBS Only

MVK Monoclonal Antibody for WB, Indirect ELISA
Cat No. 67820-1-PBS
Clone No.2F1D3

Host / Isotype

Mouse / IgG2b

Reactivity

Human

Applications

WB, Indirect ELISA

Synonyms

FLJ96772, LRBP, mevalonate kinase, MK, MVK, MVLK

Formulation:  PBS Only
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

67820-1-PBS targets MVK in WB, Indirect ELISA applications and shows reactivity with Human samples.

Tested Reactivity Human
Host / Isotype Mouse / IgG2b
Class Monoclonal
Type Antibody
Immunogen

CatNo: Ag28887

Product name: Recombinant human MVK protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 1-396 aa of BC016140

Sequence: MLSEVLLVSAPGKVILHGEHAVVHGKVALAVSLNLRTFLRLQPHSNGKVDLSLPNIGIKRAWDVARLQSLDTSFLEQGDVTTPTSEQVEKLKEVAGLPDDCAVTERLAVLAFLYLYLSICRKQRALPSLDIVVWSELPPGAGLGSSAAYSVCLAAALLTVCEEIPNPLKDGDCVNRWTKEDLELINKWAFQGERMIHGNPSGVDNAVSTWGGALRYHQGKISSLKRSPALQILLTNTKVPRNTRALVAGVRNRLLKFPEIVAPLLTSIDAISLECERVLGEMGEAPAPEQYLVLEELIDMNQHHLNALGVGHASLDQLCQVTRARGLHSKLTGAGGGGCGITLLKPGLEQPEVEATKQALTSCGFDCLETSIGAPGVSIHSATSLDSRVQQALDGL

相同性解析による交差性が予測される生物種
Full Name mevalonate kinase
Calculated molecular weight 396 aa, 42 kDa
Observed molecular weight 42 kDa
GenBank accession numberBC016140
Gene Symbol MVK
Gene ID (NCBI) 4598
RRIDAB_2918583
Conjugate Unconjugated
Form
FormLiquid
Purification MethodProtein A purification
UNIPROT IDQ03426
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

MVK (Mevalonate kinase) is a 42 kDa cytoplasmic protein that belongs to the GHMP kinase family. Mevalonate kinase catalyzes the ATP-dependent phosphorylation of mevalonic acid to form mevalonate 5-phosphate. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia, myopathy and ataxia.