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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using MRC2 Polyclonal antibody (21410-1-AP)

    WB analysis using 21410-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 21410-1-AP (MRC2 antibody) at dilution of 1:4000 incubated at room temperature for 1.5 hours.

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MRC2 Polyclonal antibody

MRC2 Polyclonal Antibody for WB, ELISA
Cat No. 21410-1-AP

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, ELISA

Synonyms

ENDO180, C-type mannose receptor 2, C-type lectin domain family 13 member E, CLEC13E, CD280

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター（国内）に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。

保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Positive WB detected inHeLa cells, Saos-2 cells, SH-SY5Y cells

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:1000-1:8000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

21410-1-AP targets MRC2 in WB, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen MRC2 fusion protein Ag15570 相同性解析による交差性が予測される生物種
Full Name mannose receptor, C type 2
Calculated molecular weight 1479 aa, 167 kDa
Observed molecular weight170 kDa
GenBank accession numberBC146647
Gene Symbol MRC2
Gene ID (NCBI) 9902
RRIDAB_3669367
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ9UBG0
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

C-type mannose receptor 2 (MRC2), also known as CD280, CLEC13E, ENDO180, KIAA0709, or UPARAP, is a type I transmembrane glycoprotein that belongs to the macrophage mannose receptor protein family (PMID: 10683150; 10636902; 9734811). It contains an N-terminal cysteine-rich domain, a fibronectin type II domain (FNII), eight C-type-lectin-like domains, and a transmembrane region followed by a small cytoplasmic domain (PMID: 34012764). MRC2 is a recycling endocytic receptor that functions in both these cellular activities by promoting cell migration and uptake of collagens for intracellular degradation (PMID: 17974964). MRC2 is expressed in several cells and organs including fibroblasts, endothelial cells, and macrophages. Altered MRC2 expression has been associated with the development and progression of different cancers, including head and neck squamous cell carcinoma, breast cancer, hepatocellular cancer, and prostate cancer (PMID: 36188226; 37666484; 17974964; 25162823).

Protocols

Product Specific Protocols
WB protocol for MRC2 antibody 21410-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols