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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using LRRC8A/SWELL1 Polyclonal antibody (17155-1-AP)

    WB analysis using 17155-1-AP (same clone as 17155-1-PBS)

    Mouse brain tissue were subjected to SDS PAGE followed by western blot with 17155-1-AP (LRRC8A/SWELL1 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17155-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using LRRC8A/SWELL1 Polyclonal antibody (17155-1-AP)

    WB analysis using 17155-1-AP (same clone as 17155-1-PBS)

    rat lung tissue were subjected to SDS PAGE followed by western blot with 17155-1-AP (LRRC8A/SWELL1 antibody) at dilution of 1:300 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 17155-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of mouse brain tissue using LRRC8A/SWELL1 Polyclonal antibody (17155-1-AP)

    IP experiment of mouse brain using 17155-1-AP (same clone as 17155-1-PBS)

    IP result of anti-LRRC8A/SWELL1 (IP:17155-1-AP, 4ug; Detection:17155-1-AP 1:800) with mouse brain tissue lysate 2100 ug. This data was developed using the same antibody clone with 17155-1-PBS in a different storage buffer formulation.

LRRC8A/SWELL1 Polyclonal antibody, PBS Only

LRRC8A/SWELL1 Polyclonal Antibody for WB, IP, Indirect ELISA
Cat No. 17155-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse, rat

Applications

WB, IP, Indirect ELISA

Synonyms

LRRC8A, HsLRRC8A, KIAA1437, Leucine-rich repeat-containing protein 8A, LRRC8

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

17155-1-PBS targets LRRC8A/SWELL1 in WB, IP, Indirect ELISA applications and shows reactivity with human, mouse, rat samples.

Tested Reactivity human, mouse, rat
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag10062

Product name: Recombinant human LRRC8A protein

Source: e coli.-derived, PET28a

Tag: 6*His

Domain: 464-810 aa of BC051322

Sequence: SIAQLTGLKELWLYHTAAKIEAPALAFLRENLRALHIKFTDIKEIPLWIYSLKTLEELHLTGNLSAENNRYIVIDGLRELKRLKVLRLKSNLSKLPQVVTDVGVHLQKLSINNEGTKLIVLNSLKKMANLTELELIRCDLERIPHSIFSLHNLQEIDLKDNNLKTIEEIISFQHLHRLTCLKLWYNHIAYIPIQIGNLTNLERLYLNRNKIEKIPTQLFYCRKLRYLDLSHNNLTFLPADIGLLQNLQNLAITANRIETLPPELFQCRKLRALHLGNNVLQSLPSRVGELTNLTQIELRGNRLECLPVELGECPLLKRSGLVVEEDLFNTLPPEVKERLWRADKEQA

相同性解析による交差性が予測される生物種
Full Name leucine rich repeat containing 8 family, member A
Calculated molecular weight 810 aa, 94 kDa
Observed molecular weight94 kDa
GenBank accession numberBC051322
Gene Symbol LRRC8A
Gene ID (NCBI) 56262
RRIDAB_2918050
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDQ8IWT6
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

LRRC8A, also named as SWELL1, KIAA1437, and LRRC8, belongs to the LRRC8 family. LRRC8A is the essential subunit of the volume-regulated anion channel (VRAC), a key regulator of cell volume homeostasis. It forms heteromeric channels with other LRRC8 family members (B-E) to transport chloride, organic osmolytes, and drugs. This channel is crucial for processes like regulatory volume decrease (RVD), cell proliferation, and migration. Dysfunction of LRRC8A-VRAC is implicated in cancer chemotherapy resistance, stroke, and immune disorders (PMID: 24790029, PMID: 39550567, PMID: 40642832). The molecular weight of LRRC8A is 94 kDa.

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