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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using LPXN Polyclonal antibody (11307-1-AP)

    WB analysis using 11307-1-AP (same clone as 11307-1-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 11307-1-AP (LPXN antibody) at dilution of 1:5000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 11307-1-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of PC-3 cells using LPXN Polyclonal antibody (11307-1-AP)

    WB analysis of PC-3 using 11307-1-AP (same clone as 11307-1-PBS)

    WB result of LPXN antibody (11307-1-AP; 1:1000; incubated at room temperature for 1.5 hours) with sh-Control and sh-LPXN transfected PC-3 cells. This data was developed using the same antibody clone with 11307-1-PBS in a different storage buffer formulation.

  • Immunoprecipitation (IP) experiment of PC-3 cells using LPXN Polyclonal antibody (11307-1-AP)

    IP experiment of PC-3 using 11307-1-AP (same clone as 11307-1-PBS)

    IP result of anti-LPXN (IP:11307-1-AP, 4ug; Detection:11307-1-AP 1:5000) with PC-3 cells lysate 1575 ug. This data was developed using the same antibody clone with 11307-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lung cancer tissue using LPXN Polyclonal antibody (11307-1-AP)

    IHC staining of human lung cancer using 11307-1-AP (same clone as 11307-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11307-1-AP (LPXN antibody) at dilution of 1:800 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11307-1-PBS in a different storage buffer formulation.

  • Immunohistochemistry (IHC) staining of human lung cancer tissue using LPXN Polyclonal antibody (11307-1-AP)

    IHC staining of human lung cancer using 11307-1-AP (same clone as 11307-1-PBS)

    Immunohistochemical analysis of paraffin-embedded human lung cancer tissue slide using 11307-1-AP (LPXN antibody) at dilution of 1:800 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0). This data was developed using the same antibody clone with 11307-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of PC-3 cells using LPXN Polyclonal antibody (11307-1-AP)

    IF Staining of PC-3 using 11307-1-AP (same clone as 11307-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed PC-3 cells using LPXN antibody (11307-1-AP) at dilution of 1:400 and Multi-rAb CoraLite ® Plus 488-Goat Anti-Rabbit Recombinant Secondary Antibody (H+L) (RGAR002). This data was developed using the same antibody clone with 11307-1-PBS in a different storage buffer formulation.

  • Featured Product
  • KD/KO Validated

LPXN Polyclonal antibody, PBS Only

LPXN Polyclonal Antibody for WB, IHC, IF/ICC, IP, Indirect ELISA
Cat No. 11307-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IHC, IF/ICC, IP, Indirect ELISA

Synonyms

LDLP, LDPL

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

11307-1-PBS targets LPXN in WB, IHC, IF/ICC, IP, Indirect ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag1845

Product name: Recombinant human LPXN protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 87-386 aa of BC019035

Sequence: TSAAAQLDELMAHLTEMQAKVAVRADAGKKHLPDKQDHKASLDSMLGGLEQELQDLGIATVPKGHCASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGTLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLFPL

相同性解析による交差性が予測される生物種
Full Name leupaxin
Calculated molecular weight 43 kDa
Observed molecular weight 45 kDa
GenBank accession numberBC019035
Gene Symbol LPXN
Gene ID (NCBI) 9404
RRIDAB_2877756
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen affinity purification
UNIPROT IDO60711
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

LPXN, also known as Leupaxin, LDPL, belongs to the paxillin family. LPXN Contributes to the regulation of cell adhesion, spreading, and cell migration and acts as a negative regulator in integrin-mediated cell adhesion events (PMID: 20543562). LPXN has four leucine-rich LD-motifs in the N-terminus and four LIM domains in the C-terminus. It may function in cell type-specific signaling by associating with PYK2, a member of the focal adhesion kinase family (PMID: 9565592). Studies in breast cancer implicate LPXN is involved in the regulation of ER action as a co-factor (PMID: 25955236). LPXN is expressed in prostate cancer cells and its expression intensity is directly linked to PCa progression (PMID: 18451096).

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