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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using LLGL1 Polyclonal antibody (22496-1-AP)

    WB analysis using 22496-1-AP (same clone as 22496-1-PBS)

    A431 cells were subjected to SDS PAGE followed by western blot with 22496-1-AP (LLGL1 antibody) at dilution of 1:800 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 22496-1-PBS in a different storage buffer formulation.

  • Immunofluorescence (IF) / fluorescent staining of HepG2 cells using LLGL1 Polyclonal antibody (22496-1-AP)

    IF Staining of HepG2 using 22496-1-AP (same clone as 22496-1-PBS)

    Immunofluorescent analysis of (-20°C Ethanol) fixed HepG2 cells using LLGL1 antibody (22496-1-AP) at dilution of 1:400 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2). This data was developed using the same antibody clone with 22496-1-PBS in a different storage buffer formulation.

LLGL1 Polyclonal antibody, PBS Only

LLGL1 Polyclonal Antibody for WB, IF/ICC, ELISA
Cat No. 22496-1-PBS

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

WB, IF/ICC, ELISA

Synonyms

lethal giant larvae homolog 1 (Drosophila), Hugl-1, Hugl1

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

22496-1-PBS targets LLGL1 in WB, IF/ICC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen

CatNo: Ag18057

Product name: Recombinant human LLGL1 protein

Source: e coli.-derived, PGEX-4T

Tag: GST

Domain: 67-212 aa of BC151838

Sequence: EFTGLHRDAATVTQMHFLTGQGRLLSLLDDSSLHLWEIVHHNGCAHLEEALSFQLPSRPGFDGASAPLSLTRVTVVLLVAAGDIAALGTEGSSVFFLDVTTLTLLEGQTLAPGEVLRSVPDDYRCGKALGPVESLQGHLRDPTKIL

相同性解析による交差性が予測される生物種
Full Name lethal giant larvae homolog 1 (Drosophila)
Calculated molecular weight 1064 aa, 115 kDa
Observed molecular weight115 kDa
GenBank accession numberBC151838
Gene Symbol LLGL1
Gene ID (NCBI) 3996
Conjugate Unconjugated
Form
FormLiquid
Purification MethodAntigen Affinity purified
UNIPROT IDQ15334
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

Lethal giant larvae (Lgl) is a scaffolding protein that regulates the establishment of apical-basal polarity in epithelial cells. The human homologs of Lgl are known as LLGL1 and LLGL2. LLGL1 is a tumor suppressor in multiple human cancers, including hepatocellular carcinoma, malignant melanoma, and colorectal cancer (PMID: 34178676; 15735678; 16170365). LLGL2 functions as a promoter of tumor growth and not as a tumor suppressor in ER+ breast cancer (PMID: 30996345).

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