Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
13336-1-PBS targets LENG8 in WB, FC (Intra), Indirect ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen |
CatNo: Ag4153 Product name: Recombinant human LENG8 protein Source: e coli.-derived, PGEX-4T Tag: GST Domain: 501-800 aa of BC028048 Sequence: EDPERELKKQKRAARFQHGHSRRLRLEPLVLQMSSLESSGADPDWQELQIVGTCPDITKHYLRLTCAPDPSTVRPVAVLKKSLCMVKCHWKEKQDYAFACEQMKSIRQDLTVQGIRTEFTVEVYETHARIALEKGDHEEFNQCQTQLKSLYAENLPGNVGEFTAYRILYYIFTKNSGDITTELAYLTRELKADPCVAHALALRTAWALGNYHRFFRLYCHAPCMSGYLVDKFADRERKVALKAMIKTFRPALPVSYLQAELAFEGEAACRAFLEPLGLAYTGPDNSSIDCRLSLAQLSAF 相同性解析による交差性が予測される生物種 |
| Full Name | leukocyte receptor cluster (LRC) member 8 |
| Calculated molecular weight | 800 aa, 88 kDa |
| Observed molecular weight | 86-88 kDa |
| GenBank accession number | BC028048 |
| Gene Symbol | LENG8 |
| Gene ID (NCBI) | 114823 |
| RRID | AB_1167573 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q96PV6 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
LENG8 is the core factor of the key RNA quality control system discovered in recent years, which plays a goalkeeper role in the regulation of eukaryotic gene expression. LENG8 promotes the recruitment of PAXT complex and RNA exonuclease, and mediates the degradation of abnormal RNA. It is a multifunctional evolutionarily conserved protein, which plays a key role from yeast to human beings. It is an important node molecule connecting gene post-transcriptional processing, RNA quality control and cell energy metabolism.