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Validation Data Gallery

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  • Immunofluorescence (IF) / fluorescent staining of SH-SY5Y cells using L1CAM Recombinant antibody (84034-5-RR)

    IF Staining of SH-SY5Y using 84034-5-RR

    Immunofluorescent analysis of (4% PFA) fixed SH-SY5Y cells using L1CAM antibody (84034-5-RR, Clone: 240978A7 ) at dilution of 1:500 and CoraLite®488-Conjugated Goat Anti-Rabbit IgG(H+L) (SA00013-2).

  • Affinity and Kinetic Characterization of 84034-5-RR

    Affinity and Kinetic Characterization of 84034-5-RR

    Biolayer interferometry (BLl) kinetic assays of 84034-5-RR against Human L1CAM were performed. The affinity constant is 0.522 nM.

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L1CAM/CD171 Recombinant antibody

L1CAM/CD171 Uni-rAbTM Recombinant Antibody for IF/ICC, ELISA
Cat No. 84034-5-RR
Clone No.240978A7

Host / Isotype

Rabbit / IgG

Reactivity

human

Applications

IF/ICC, ELISA

Synonyms

L1CAM, 240978A7, CAML1, CD171, HSAS

Formulation:  PBS and Azide
PBS and Azide
PBS Only
Conjugate:  Unconjugated
Unconjugated
CoraLite® Plus 488
Size/Concentration: 

-/ -

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Tested Applications

Positive IF/ICC detected inSH-SY5Y cells

Recommended dilution

ApplicationDilution
Immunofluorescence (IF)/ICCIF/ICC : 1:250-1:1000
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Product Information

84034-5-RR targets L1CAM/CD171 in IF/ICC, ELISA applications and shows reactivity with human samples.

Tested Reactivity human
Host / Isotype Rabbit / IgG
Class Recombinant
Type Antibody
Immunogen L1CAM/CD171 fusion protein Eg0209 相同性解析による交差性が予測される生物種
Full Name L1 cell adhesion molecule
Calculated molecular weight 1257 aa, 140 kDa
GenBank accession numberBC126229
Gene Symbol L1CAM
Gene ID (NCBI) 3897
RRIDAB_3671603
Conjugate Unconjugated
Form Liquid
Purification MethodProtein A purfication
UNIPROT IDP32004
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

L1CAM, also known as NCAM-L1 or CD171, is a cell adhesion molecule of the immunoglobulin superfamily. It is a 200-220 kDa transmembrane glycoprotein composed of six Ig-like domains and five fibronectin type III repeats followed by a transmembrane region and a highly conserved cytoplasmic tail (PMID: 3412448; 22796939). L1CAM is primarily expressed in the nervous system and is involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, cerebellar granule cell migration, neurite outgrowth on Schwann cells and interactions among epithelial cells of intestinal crypts (PMID: 3412448; 10767310). L1CAM is overexpressed in many human cancers and is often associated with bad prognosis (PMID: 27267927; 26111503).

Protocols

Product Specific Protocols
IF protocol for L1CAM/CD171 antibody 84034-5-RRDownload protocol
Standard Protocols
Click here to view our Standard Protocols