Validation Data Gallery
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Tested Applications
| Positive WB detected in | BxPC-3 cells, PC-3 cells, U-251 cells, SK-BR-3 cells, MDA-MB-231 cells, LN-229 cells |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:5000-1:50000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
86962-12-RR targets KAT6B/MORF in WB, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | MYST histone acetyltransferase (monocytic leukemia) 4 |
| Calculated molecular weight | 2073 aa, 231 kDa |
| Observed molecular weight | 231-250 kDa |
| GenBank accession number | BC150618 |
| Gene Symbol | MYST4 |
| Gene ID (NCBI) | 23522 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q8WYB5 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
KAT6B (also known as MORF or MYST4) is a member of the MYST family of histone acetyltransferases that catalyzes acetylation of histones H3 and H4, thereby regulating chromatin structure and gene transcription. It plays essential roles in brain development, hematopoiesis, and skeletal morphogenesis. Mutations in the KAT6B gene cause developmental disorders such as Genitopatellar syndrome and Ohdo syndrome, while chromosomal translocations generating KAT6B-CREBBP fusion proteins drive a subset of acute myeloid leukemia.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for KAT6B/MORF antibody 86962-12-RR | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |