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Validation Data Gallery

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  • Western Blot (WB) analysis of various lysates using ITPR3 Polyclonal antibody (20729-1-AP)

    WB analysis using 20729-1-AP

    Various lysates were subjected to SDS PAGE followed by western blot with 20729-1-AP (ITPR3 antibody) at dilution of 1:500 incubated at room temperature for 1.5 hours.

  • Immunohistochemistry (IHC) staining of mouse small intestine tissue using ITPR3 Polyclonal antibody (20729-1-AP)

    IHC staining of mouse small intestine using 20729-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse small intestine tissue slide using 20729-1-AP (ITPR3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

  • Immunohistochemistry (IHC) staining of mouse colon tissue using ITPR3 Polyclonal antibody (20729-1-AP)

    IHC staining of mouse colon using 20729-1-AP

    Immunohistochemical analysis of paraffin-embedded mouse colon tissue slide using 20729-1-AP (ITPR3 antibody) at dilution of 1:200 (under 40x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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ITPR3 Polyclonal antibody

ITPR3 Polyclonal Antibody for WB, IHC, ELISA
Cat No. 20729-1-AP
Publications(1)

Host / Isotype

Rabbit / IgG

Reactivity

human, mouse

Applications

WB, IHC, ELISA

Synonyms

InsP3R3, IP3 receptor isoform 3, IP3R, IP3R 3, IP3R3, ITPR3, Type 3 InsP3 receptor

Formulation:  PBS and Azide
PBS and Azide
Conjugate:  Unconjugated
Unconjugated
Size/Concentration: 

-/ -

ご購入について

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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター（国内）に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。

保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Positive WB detected inHeLa cells
Positive IHC detected inmouse colon tissue, mouse small intestine tissue
Note: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0

Recommended dilution

ApplicationDilution
Western Blot (WB)WB : 1:500-1:1000
Immunohistochemistry (IHC)IHC : 1:50-1:500
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.
Sample-dependent, Check data in validation data gallery.

Published Applications

WBSee 1 publications below

Product Information

20729-1-AP targets ITPR3 in WB, IHC, ELISA applications and shows reactivity with human, mouse samples.

Tested Reactivity human, mouse
Cited Reactivityhuman
Host / Isotype Rabbit / IgG
Class Polyclonal
Type Antibody
Immunogen Peptide 相同性解析による交差性が予測される生物種
Full Name inositol 1,4,5-triphosphate receptor, type 3
Calculated molecular weight 304 kDa
Observed molecular weight250-300 kDa
GenBank accession numberNM_002224
Gene Symbol ITPR3
Gene ID (NCBI) 3710
RRIDAB_3669343
Conjugate Unconjugated
Form Liquid
Purification MethodAntigen affinity purification
UNIPROT IDQ14573
Storage Buffer PBS with 0.02% sodium azide and 50% glycerol , pH 7.3
Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage.

Background Information

ITPRs family have three members: ITPR1, ITPR2 and ITPR3. For ITPR3, it is associated with cervical squamous cell carcinoma, glioblastoma, cholangiocarcinoma and other cancers. Inositol 1,4, 5-triphosphate receptor type 3 (ITPR3) was found to be apical-located in bile duct cells, and disruption of lipid raft in the segregated bile duct unit (IBDU) redistributes ITPR3 and impairs Ca2+ waves. (PMID: 35580861, PMID:35852334)

Protocols

Product Specific Protocols
WB protocol for ITPR3 antibody 20729-1-APDownload protocol
IHC protocol for ITPR3 antibody 20729-1-APDownload protocol
Standard Protocols
Click here to view our Standard Protocols

Publications

SpeciesApplicationTitle
humanWB

Mol Cell Endocrinol

High glucose elevates intracellular calcium level and induces ferroptosis in glomerular endothelial cells through the miR-223-3p/ITPR3 pathway

Authors - Dekai Wang
View Article