Validation Data Gallery
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Tested Applications
| Positive WB detected in | U-251 cells, fetal human brain tissue |
Recommended dilution
| Application | Dilution |
|---|---|
| Western Blot (WB) | WB : 1:500-1:1000 |
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
| Sample-dependent, Check data in validation data gallery. | |
Product Information
12193-1-AP targets ITM2B in WB, ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | ITM2B fusion protein Ag2831 相同性解析による交差性が予測される生物種 |
| Full Name | integral membrane protein 2B |
| Calculated molecular weight | 266 aa, 30 kDa |
| Observed molecular weight | 40 kDa |
| GenBank accession number | BC016148 |
| Gene Symbol | ITM2B |
| Gene ID (NCBI) | 9445 |
| RRID | AB_3669134 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| UNIPROT ID | Q9Y287 |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol , pH 7.3 |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
ITM2B plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. It plays a role in the induction of neurite outgrowth and functions as a protease inhibitor by blocking access of secretases to APP cleavage sites.
Protocols
| Product Specific Protocols | |
|---|---|
| WB protocol for ITM2B antibody 12193-1-AP | Download protocol |
| Standard Protocols | |
|---|---|
| Click here to view our Standard Protocols |