Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
82766-15-PBS targets IL-22 in WB, Indirect ELISA applications and shows reactivity with human samples.
| Tested Reactivity | human |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
Recombinant protein 相同性解析による交差性が予測される生物種 |
| Full Name | interleukin 22 |
| Observed molecular weight | 20 kDa |
| GenBank accession number | BC066263 |
| Gene Symbol | IL-22 |
| Gene ID (NCBI) | 50616 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q9GZX6 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
Interleukin-22 (IL-22) is a member of the IL-10 cytokine family, primarily produced by immune cells such as group 3 innate lymphoid cells (ILC3s), Th17 cells, Th22 cells, and γδ T cells (PMID: 25706098). Its unique feature lies in targeting non-immune epithelial and stromal cells, which exclusively express the heterodimeric IL-22 receptor (IL-22R1 and IL-10R2). IL-22 plays a dual role in immunity and tissue homeostasis: it promotes epithelial cell proliferation, regeneration, and barrier integrity through the upregulation of antimicrobial peptides (e.g., defensins) and mucin production, thereby enhancing defense against extracellular pathogens. However, IL-22 can also drive pathological inflammation in autoimmune and chronic inflammatory diseases (e.g., psoriasis, colitis) when dysregulated. This functional dichotomy highlights its context-dependent nature as both a protective mediator and a pathogenic effector (PMID: 20498020).