Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
98532-2-PBS targets IL-17RA in FC applications and shows reactivity with mouse samples.
| Tested Reactivity | mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Eg2584 Product name: Recombinant Mouse IL-17RA protein (rFc Tag) Source: mammalian cells-derived, pHZ-KIsec-C-rFc Tag: C-rFc Domain: 32-322 aa of NM_008359.2 Sequence: SPRLLDFPAPVCAQEGLSCRVKNSTCLDDSWIHPKNLTPSSPKNIYINLSVSSTQHGELVPVLHVEWTLQTDASILYLEGAELSVLQLNTNERLCVKFQFLSMLQHHRKRWRFSFSHFVVDPGQEYEVTVHHLPKPIPDGDPNHKSKIIFVPDCEDSKMKMTTSCVSSGSLWDPNITVETLDTQHLRVDFTLWNESTPYQVLLESFSDSENHSCFDVVKQIFAPRQEEFHQRANVTFTLSKFHWCCHHHVQVQPFFSSCLNDCLRHAVTVPCPVISNTTVPKPVADYIPLW 相同性解析による交差性が予測される生物種 |
| Full Name | interleukin 17 receptor A |
| Calculated molecular weight | 98kDa |
| GenBank accession number | NM_008359.2 |
| Gene Symbol | Il17ra |
| Gene ID (NCBI) | 16172 |
| RRID | AB_3746159 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q60943 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
IL-17 is a proinflammatory cytokine. IL-17 can signal as homodimers or heterodimers through a heterodimeric receptor formed by IL-17 receptor A (IL-17RA) and IL-17 receptor C (IL-17RC) subunits. IL-17RA is ubiquitously expressed in both the epithelial and hematopoietic cell compartments. IL-17/IL-17RA signaling plays an important physiological role in regulating the mucosal host defense against invading microorganisms, but it can also play pathogenic roles in several inflammatory or autoimmune conditions; furthermore, it has been described as pro-tumorigenic in several cancer types.