Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| This reagent has been tested for flow cytometric analysis. It is recommended that this reagent should be titrated in each testing system to obtain optimal results. | |
Product Information
98556-1-PBS targets IL-17C in FC (Intra) applications and shows reactivity with mouse samples.
| Tested Reactivity | mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Recombinant |
| Type | Antibody |
| Immunogen |
CatNo: Eg2840 Product name: Recombinant Mouse IL-17C protein (rFc Tag) Source: mammalian cells-derived, V37 Tag: C-rFc Domain: 15-194 aa of NM_145834.3 Sequence: HQDPPSWGKPRSHRTLRCYSAEELSHGQAPPHLLTRSARWEQALPVALVASLEATGHRRQHEGPLAGTQCPVLRPEEVLEADTHERSISPWRYRIDTDENRYPQKLAVAECLCRGCINAKTGRETAALNSVQLLQSLLVLRRQPCSRDGTADPTPGSFAFHTEFIRVPVGCTCVLPRSTQ 相同性解析による交差性が予測される生物種 |
| Full Name | interleukin 17C |
| Calculated molecular weight | 22 kDa |
| GenBank accession number | NM_145834.3 |
| Gene Symbol | Il17c |
| Gene ID (NCBI) | 234836 |
| RRID | AB_3746176 |
| Conjugate | Unconjugated |
| Form | |
| Form | Liquid |
| Purification Method | Protein A purification |
| UNIPROT ID | Q8K4C5 |
| Storage Buffer | PBS only{{ptg:BufferTemp}}7.3 |
| Storage Conditions | Store at -80°C. |
Background Information
IL-17C is a member of the IL-17 cytokine family, was cloned from a human fetal kidney library in 2000 (PMID: 10639155). The IL-17 family comprises at least 6 proinflammatory cytokines that share a conserved cystine-knot structure but diverge at the N-terminus. IL-17 family members are glycoproteins that induce local cytokine production and recruit granulocytes to sites of inflammation (PMID: 15485625; 11574464). IL-17C is selectively induced in epithelia by bacterial challenge and inflammatory stimuli (PMID: 21993848). IL-17RE is a receptor specific to IL-17C and has an essential role in host mucosal defense against infection (PMID: 21993849).