IHCeasy® INSM2 Ready-To-Use IHC Kit
INSM2 Ready-to-use reagent kit for IHC.
Reactivity
Human, Rat
Sample Type
FFPE tissue
Cat no : KHC3111
Synonyms
IA6, INSM Transcriptional Repressor 2 , Insulinoma-associated protein 2, Nbla106, Zinc finger protein IA-6
Validation Data Gallery
Product Information
KHC3111 is a ready-to-use IHC kit for staining of INSM2. The kit provides all reagents, from antigen retrieval to cover slip mounting, that require little to no diluting or handling prior to use. Simply apply the reagents to your sample slide according to the protocol and you're steps away from obtaining high-quality IHC data.
| Product name | IHCeasy® INSM2 Ready-To-Use IHC Kit |
| Sample type | FFPE tissue |
| Assay type | Immunohistochemistry |
| Primary antibody type | Rabbit Polyclonal |
| Secondary antibody type | Polymer-HRP-Goat anti-Rabbit |
| Reactivity | Human, Rat |
Kit components
| Component | Size | Concentration |
|---|---|---|
| Antigen Retrieval Buffer | 100 mL | 50× |
| Washing Buffer | 100 mL ×2 | 20× |
| Blocking Buffer | 5 mL | RTU |
| Primary Antibody | 5 mL | RTU |
| Secondary Antibody | 5 mL | RTU |
| Chromogen Component A | 0.2 mL | RTU |
| Chromogen Component B | 4 mL | RTU |
| Signal Enhancer | 5 mL | RTU |
| Counter Staining Reagent | 5 mL | RTU |
| Mounting Media | 5 mL | RTU |
| Datasheet | 1 Copy | |
| Manual | 1 Copy |
Background Information
INSM2 (Insulinoma-associated protein 2) is a zinc-finger protein belonging to the transcription factor family and has transcriptional repressive functions. It may exert growth-inhibitory or tumor-suppressive effects in hepatocytes and certain neurons. The primary function of INSM2 involves the regulation of gene expression, particularly the repression of insulin gene expression in non-pancreatic cells. Additionally, INSM2 is upregulated in neuroblastoma and is associated with poor prognosis. It promotes tumor development by affecting lipid metabolism through the regulation of the mTOR signaling pathway.
Properties
| Storage Instructions | All the reagents are stored at 2-8°C. The kit is stable for 6 months from the date of receipt. |
| Synonyms | IA6, INSM Transcriptional Repressor 2 , Insulinoma-associated protein 2, Nbla106, Zinc finger protein IA-6 |