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Validation Data Gallery

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  • Western Blot (WB) analysis of human placenta tissue using IGFBP1 Monoclonal antibody (60717-8-Ig)

    WB analysis of human placenta using 60717-8-Ig (same clone as 60717-8-PBS)

    human placenta tissue were subjected to SDS PAGE followed by western blot with 60717-8-Ig (IGFBP1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60717-8-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of human plasma using IGFBP1 Monoclonal antibody (60717-8-Ig)

    WB analysis of human plasma using 60717-8-Ig (same clone as 60717-8-PBS)

    human plasma were subjected to SDS PAGE followed by western blot with 60717-8-Ig (IGFBP1 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60717-8-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of rabbit liver tissue using IGFBP1 Monoclonal antibody (60717-8-Ig)

    WB analysis of rabbit liver using 60717-8-Ig (same clone as 60717-8-PBS)

    rabbit liver tissue were subjected to SDS PAGE followed by western blot with 60717-8-Ig (IGFBP1 antibody) at dilution of 1:10000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60717-8-PBS in a different storage buffer formulation.

  • Western Blot (WB) analysis of various lysates using IGFBP1 Monoclonal antibody (60717-8-Ig)

    WB analysis using 60717-8-Ig (same clone as 60717-8-PBS)

    Various lysates were subjected to SDS PAGE followed by western blot with 60717-8-Ig (IGFBP1 antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. This data was developed using the same antibody clone with 60717-8-PBS in a different storage buffer formulation.

IGFBP1 Monoclonal antibody, PBS Only

IGFBP1 Monoclonal Antibody for WB, Indirect ELISA
Cat No. 60717-8-PBS
Clone No.4A9D2

Host / Isotype

Mouse / IgG1

Reactivity

human, rabbit

Applications

WB, Indirect ELISA

Synonyms

AFBP, hIGFBP 1, IBP 1, IBP1, IBP-1

Formulation:  PBS Only
PBS, Azide, Glycerol
PBS Only
Conjugate:  Unconjugated
Size/Concentration: 

-/ -

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国内在庫・納期について

約2万点のプロテインテック製品をコスモバイオ社物流センター（国内）に在庫しています。国内在庫の有無はコスモバイオ社ホームページの「品番検索」でカタログ番号を検索して確認できます。

保証・サポートについて

テクニカルサポートまたはご購入後1年間の交換／補填対応を承ります。詳細はこちらをご覧ください。

Tested Applications

Recommended dilution

ApplicationDilution
It is recommended that this reagent should be titrated in each testing system to obtain optimal results.

Product Information

60717-8-PBS targets IGFBP1 in WB, Indirect ELISA applications and shows reactivity with human, rabbit samples.

Tested Reactivity human, rabbit
Host / Isotype Mouse / IgG1
Class Monoclonal
Type Antibody
Immunogen

CatNo: Eg0951

Product name: Recombinant Human IGFBP-1 protein (His Tag)

Source: mammalian cells-derived, pHZ-KIsec-C-6*HIS

Tag: C-6*HIS

Domain: 26-259 aa of NM_000596.4

Sequence: APWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN

相同性解析による交差性が予測される生物種
Full Name IGF binding protein 1
Calculated molecular weight28 kDa
Observed molecular weight 28-35 kDa
GenBank accession numberNM_000596.4
Gene Symbol IGFBP1
Gene ID (NCBI) 3484
RRIDAB_3743231
Conjugate Unconjugated
Form
FormLiquid
Purification MethodProtein G purification
UNIPROT IDP08833
Storage Buffer PBS only{{ptg:BufferTemp}}7.3
Storage ConditionsStore at -80°C.

Background Information

IGF-binding proteins (IGFBPs) family contains members like IGFBP-1, -2, -3, -4,-5 and-6. IGFBPs prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. IGF-I physically interacts with IGFBP-1 and that IGFBP-1 also binds to an integrin receptor, but the effect of IGFBP-1 on cell migration may be independent of IGF-I and is probably mediated through the alpha 5 beta 1 integrin. Transgenic mice models demonstrated that IGFBPs played important roles in the pathogenesis of obesity and INS resistance. Studies conducted in humans demonstrated the close relation between IGFBPs and the components of the metabolic syndrome.

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