ICMT Polyclonal antibody
ICMT Polyclonal Antibody for ELISA
Host / Isotype
Rabbit / IgG
Reactivity
human, mouse, rat
Applications
ELISA
Conjugate
Unconjugated
Cat no : 18983-1-AP
Synonyms
Validation Data Gallery
Tested Applications
Recommended dilution
| Application | Dilution |
|---|---|
| Sample-dependent, check data in validation data gallery | |
Product Information
18983-1-AP targets ICMT in ELISA applications and shows reactivity with human, mouse, rat samples.
| Tested Reactivity | human, mouse, rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Peptide 相同性解析による交差性が予測される生物種 |
| Full Name | isoprenylcysteine carboxyl methyltransferase |
| Calculated molecular weight | 32 kDa |
| GenBank accession number | NM_012405 |
| Gene symbol | ICMT |
| Gene ID (NCBI) | 23463 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Purification Method | Antigen affinity purification |
| Storage Buffer | PBS with 0.02% sodium azide and 50% glycerol pH 7.3. |
| Storage Conditions | Store at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for -20oC storage. |
Background Information
ICMT, also named as PCCMT and PPMT, belongs to the isoprenylcysteine O-methyltransferase family. ICMT is the third of three enzymes that posttranslationally modify isoprenylated C-terminal cysteine residues in certain proteins and target those proteins to the cell membrane. It localizes to the endoplasmic reticulum. Alternative splicing may result in other transcript variants, but the biological validity of those transcripts has not been determined. It is ubiquitously expressed. It expressed at higher levels in the cerebellum and putamen than in other brain regions and abundant expression seen in the Purkinje cells and pontine neurons.
