Recombinant Human PGLYRP1 protein (mFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
mFc Tag
Activity
not tested
Cat no : Eg3666
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human PGLYRP1 protein Gln22-Pro196 (Accession# O75594) with a mouse IgG Fc tag at the C-terminus. |
| GeneID | 8993 |
| Accession | O75594 |
| PredictedSize | 46.1 kDa |
| SDS-PAGE | 44-53 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Peptidoglycan recognition protein 1 (PGLYRP1, also known as PGRP-S) belongs to a family of evolutionary conserved innate immunity proteins, which in mammals also include PGLYRP2, PGLYRP3, and PGLYRP4. PGLYRP1 is highly expressed in polymorphonuclear leukocytes and to a lesser extent in many non-immune cells. It recognizes bacterial peptidoglycan and functions in antibacterial immunity and inflammation. PGLYRP1 has been identified as a ligand for TREM-1.
References:
1. Guan R. et al. (2007). Trends Microbiol. 15(3):127-134. 2. Dziarski R. et al. (2010). Innate Immun. 16(3):168-174. 3. Read CB. et al. (2015). J Immunol. 194(4):1417-1421.