Recombinant Human PGLYRP1 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg3122
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human PGLYRP1 protein Gln22-Pro196 (Accession# O75594) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 8993 |
| Accession | O75594 |
| PredictedSize | 45.0 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Peptidoglycan recognition protein 1 (PGLYRP1, also known as PGRP-S) belongs to a family of evolutionarily conserved innate immunity proteins, which in mammals also include PGLYRP2, PGLYRP3, and PGLYRP4. PGLYRP1 is highly expressed in polymorphonuclear leukocytes and to a lower extent in many non-immune cells. It recognizes bacterial peptidoglycan and functions in antibacterial immunity and inflammation. PGLYRP1 has been identified as a ligand for TREM-1.
References:
1. Guan, Rongjin, and Roy A Mariuzza. Trends in microbiology vol. 15,3 (2007): 127-34. 2. Dziarski, Roman, and Dipika Gupta. Innate immunity vol. 16,3 (2010): 168-74. 3. Read, Christine B et al. Journal of immunology (Baltimore, Md. : 1950) vol. 194,4 (2015): 1417-21.