Recombinant Human OXT protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg2237
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human OXT protein Ala32-Arg125 (Accession# P01178) with a rabbit IgG Fc tag at the N-terminus. |
| GeneID | 5020 |
| Accession | P01178 |
| PredictedSize | 36.8 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Oxytocin (OXT) is a neuropeptide involved in social-approach behaviors in humans and others mammals. OXT is located on chromosome 20p13 and codes for a precursor protein that is synthetized to produce oxytocin and neurophysin I, and neurophysin I is the carrier protein for oxytocin. Oxytocin causes contraction of the smooth muscle of the uterus and of the mammary gland. Acts by binding to oxytocin receptor (OXTR).
References:
1. Haas, Brian W et al. Proceedings of the National Academy of Sciences of the United States of America vol. 113,27 (2016): E3816-23. 2. Rao, V V et al. Cytogenetics and cell genetics vol. 61,4 (1992): 271-3. 3. Xu, Yang et al. Journal of human genetics vol. 53,7 (2008): 637-643. 4. Dutertre, Sébastien et al. The Journal of biological chemistry vol. 283,11 (2008): 7100-8.