Recombinant Human NRG2 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg4172
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human NRG2 protein Cys112-Lys404 (Accession# O14511-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 9542 |
| Accession | O14511-1 |
| PredictedSize | 58.9 kDa |
| SDS-PAGE | 65-85 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
NRG2 is a novel member of the neuregulin family of growth and differentiation factors. By interacting with the ERBB family of receptors, this protein induces the growth and differentiation of epithelial, neuronal, glial and other cell types. The gene consists of 12 exons and the genomic structure is similar to that of neuregulin 1, another member of the neuregulin family of ligands. The products of these genes mediate different biological processes by acting at different sites in tissues and eliciting different biological responses in cells. This gene is close to the Charcot-Marie-Tooth demyelinating disease locus, but does not cause the disease.
References:
1.Yan L. et al. (2018) Mol Psychiatry. 23(5):1233-1243. 2.Falls DL. (2003) Exp Cell Res. 284(1):14-30. 3.Zhao WJ. et al. (2021) Folia Neuropathol. 59(2):189-197. 4.Czarnek M. et al. (2020) Mol Neurobiol. 57(4):1799-1813.