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Recombinant Human NBL1 protein (rFc Tag)(HPLC verified)

Species

Human

Purity

>90 %, SDS-PAGE
>90 %, SEC-HPLC

Tag

rFc Tag

Activity

not tested

Cat no : Eg2940

Validation Data Gallery

  • Purity of Recombinant Human NBL1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human NBL1 was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

  • The purity of Human NBL1 was greater than 90% as determined by SEC-HPLC.

    The purity of Human NBL1 was greater than 90% as determined by SEC-HPLC.

Product Information

Purity >90 %, SDS-PAGE
>90 %, SEC-HPLC
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human NBL1 protein Ala17-Asp181 (Accession# P41271-1) with a rabbit IgG Fc tag at the C-terminus.
GeneID 4681
Accession P41271-1
PredictedSize 43.7 kDa
SDS-PAGE 45-55 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

NBL1 (neuroblastoma suppression of tumorigenicity 1), also named as DAN, is the founding member of the DAN subfamily. It was originally identified as a putative tumor suppressor gene in a transformed fibroblast rat model, whereby it was significantly down-regulated in v-src-transformed rat fibroblasts. The MW of this protein is 19 kDa, and this antibody specially recognises the 19 kDa protein.

References:

1. Tsai CH. et al.  (2023) Biomolecules. 13(11):1570. 
2. Ladenstein R. et al. (2018) Lancet Oncol. 19(12):1617-1629. 
3. Lu L. et al. (2022) Oncogenesis. 11(1):21. 
4. Du J. et al. (2023) Thorac Cancer. 14(30):3032-3041. 
5. Wang A. et al. (2022) Parasitol Res. 121(5):1369-1378.
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