Recombinant Human LBP protein (His Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
His Tag
Activity
not tested
Cat no : Eg0651
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human LBP protein Ala26-Val481(Accession# P18428) with a His tag at the C-terminus. |
| GeneID | 3929 |
| Accession | P18428 |
| PredictedSize | 55.4 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Lipopolysaccharide-binding protein (LBP) is a soluble acute-phase protein primarily produced by hepatocytes and plays a crucial role in the innate immune response to Gram-negative bacterial infections. It binds to lipopolysaccharides (LPS) on the bacterial surface, facilitating the transfer of LPS to CD14 and TLR4 receptors on immune cells, thereby initiating inflammatory signaling pathways. LBP levels increase significantly during infections and sepsis, making it a potential biomarker for these conditions. Additionally, LBP has been implicated in modulating immune responses in various inflammatory and autoimmune diseases.
References:
1. Zhang, Qilun et al. Nature communications vol. 15,1 3213. 13 Apr. 2024. 2. Fang, Mingqian et al. Immunity vol. 56,3 (2023): 620-634.e11. 3. Meng, Leilei et al. Frontiers in immunology vol. 12 681810. 6 Jul. 2021. 4. Yu, Yang, and Guohua Song. Advances in experimental medicine and biology vol. 1276 (2020): 27-35.