Recombinant Human KIR3DL1/CD158E protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg3528
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human KIR3DL1 protein His22-His340 (Accession# P43629-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 3811 |
| Accession | P43629-1 |
| PredictedSize | 60.8 kDa |
| SDS-PAGE | 60-85 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. The KIR3DL1 (also named CD158E) polymorphism has been correlated with various diseases, hematopoietic stem cell transplantation (HSCT) outcomes, and viral infections.
References:
1. Dupont, B et al. Tissue antigens vol. 49,6 (1997): 557-63. 2. Campbell, Kerry S, and Amanda K Purdy. Immunology vol. 132,3 (2011): 315-25. 3. Legrand, Nolwenn et al. Cancers vol. 15,10 ( 2023) 2754.