Recombinant Human JAM2 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg2914
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human JAM2 protein Phe29-Asn236 (Accession# P57087-1) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 58494 |
| Accession | P57087-1 |
| PredictedSize | 48.8 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Junctional adhesion molecules (JAMs) are integral membrane proteins belonging to the immunoglobulin (Ig) superfamily. JAMs are expressed by leukocytes, platelets, endothelial, and epithelial cells and localized at the tight junction of polarized cells and on the cell surface of leukocytes. JAM-2, also known as VE-JAM or JAM-B, is specifically expressed in lymphatic endothelial cells and endothelial venules. JAM2 regulates cell-cell adhesion and signaling by interacting with other tight junction proteins such as PAR-3 and ZO-1.
References:
1.Ebnet, Klaus et al. Journal of cell science vol. 117,Pt 1 (2004): 19-29. 2.Garrido-Urbani, S et al. Cell and tissue research vol. 355,3 (2014): 701-15. 3.Aurrand-Lions, M et al. Blood vol. 98,13 (2001): 3699-707. 4.Ebnet, Klaus et al. Journal of cell science vol. 116,Pt 19 (2003): 3879-91.