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Host
0
Species Reactivity
0
Species Reactivity
0
Conjugate
0
Conjugate
0
Compatible Species
0
Conjugate
0
×

Target

Host

Species Reactivity

Species Reactivity

Conjugate

Conjugate

Purchase

Recombinant Human IL-7RA/CD127 protein (His Tag)

Species

Human

Purity

>90 %, SDS-PAGE

Tag

His Tag

Activity

not tested

Cat no : Eg1279

Validation Data Gallery

  • Purity of Recombinant Human IL-7RA was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

    Purity of Recombinant Human IL-7RA was determined by SDS-PAGE. The protein was resolved in an SDS-PAGE in reducing (R) and non-reducing (NR) conditions and stained using Coomassie blue.

Product Information

Purity >90 %, SDS-PAGE
Endotoxin <0.1 EU/μg protein, LAL method
Activity 
Not tested
Expression HEK293-derived Human IL-7RA protein Glu21-Asp239 (Accession# P16871-1 (I66T, V138I)) with a His tag at the C-terminus.
GeneID 3575
Accession P16871-1
PredictedSize 26.3 kDa
SDS-PAGE 38-50 kDa, reducing (R) conditions
Formulation Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization.
Reconstitution Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water.
Storage Conditions
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
  • Until expiry date, -20℃ to -80℃ as lyophilized proteins.
  • 3 months, -20℃ to -80℃ under sterile conditions after reconstitution.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature.

Background

IL-7R is a heterodimer composed of two chains, the α chain IL-7RA (also known as CD127) and the common cytokine receptor γ chain IL-2Rγ(also known as CD132). CD127 is a type I membrane glycoprotein expressed on thymocytes, B cell precursors, most T cells, and some lymphoid and myeloid cells. CD127 can also act as a receptor for thymic stromal lymphopoietin (TSLP). The levels of soluble form of CD127 (sCD127) could be used as a biomarker for septic shock, tuberculosis, and systemic lupus erythematosus.

References:

1.Daniele N. et al. (2011). Pathol Res Pract.15;207(4):209-15.
2.Wang C. et al. (2022). Int J Mol Sci. 8;23(18):10412.          
3.Barros PO. et al. (2021). Immunotargets Ther. 8;10:47-62.