Recombinant Human IGFBP-6 protein (His Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
His Tag
Activity
not tested
Cat no : Eg3437
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human IGFBP-6 protein Arg28-Gly240 (Accession# P24592) with a His tag at the C-terminus. |
| GeneID | 3489 |
| Accession | P24592 |
| PredictedSize | 23.7 kDa |
| SDS-PAGE | 27-35kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
IGFBP-6 (Insulin-like Growth Factor Binding Protein-6) is a member of the insulin-like growth factor binding protein family, which plays a crucial role in regulating the actions of insulin-like growth factors (IGFs). IGFBP-6 is involved in the immune response, particularly in human dendritic cells (DCs), and has been implicated in different human diseases. IGFBP-6 has been implicated in the biology of tumors, playing a controversial role. It is considered a protein of interest in cancer development and progression, with direct relations to immunological functions and inflammation activities in glioma, potentially serving as a therapeutic target for glioma immunotherapy
References:
1. Leon A Bach. et al.(2015). J Cell Commun Signal. 9(2):189–200. 2. Arcangelo Liso. et al. (2022). Int J Mol Sci. 23(8):4358.