|Cell culture supernatants||82%||75%-98%|
Granulysin (GNLY) is a member of the saposin-like protein (SAPLIP) family that is a cytolytic and proinflammatory molecule expressed by activated human cytotoxic T cells and NK cells, exhibiting lytic activity against a variety of microorganisms and tumors. Granulysin is produced as an intact 15-kDa form, and portions are then cleaved at the amino and carboxy termini to produce a 9-kDa form. Granulysin has broad clinical relevance to a wide variety of diseases, including infections, cancer, transplantation, skin afflictions and reproductive complications. Elevation of Granulysin expression and levels in tissue and serum has been reported in infections, autoimmune diseases, transplant rejection. Granulysin expression has been widely correlated with good outcomes in a variety of cancers.