Recombinant Human FGL1 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg2765
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human FGL1 protein Leu23-Ile312 (Accession# Q08830) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 2267 |
| Accession | Q08830 |
| PredictedSize | 60 kDa |
| SDS-PAGE | 55-65 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in 20mM Tris, 300mM NaCl ,pH8.0. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Fibrinogen-like 1 (FGL1), also termed hepatocyte-derived fibrinogen-related protein 1 (HFREP1) or hepassocin, is a predominantly liver expressed protein that has been implicated as both a hepatoprotectant and a hepatocyte mitogen. FGL1 expression is decreased in hepatocellular carcinoma (HCC), and it may play a role in the development of hepatocellular carcinomas.
References:
1. Hara, H et al. Biochimica et biophysica acta vol. 1520,1 (2001): 45-53. 2. Li, Chang-Yan et al. Gut vol. 59,6 (2010): 817-26. 3. Chen, Jiongming et al. Biomarker research vol. 12,1 53. 31 May. 2024.