Recombinant Human FGFRL1 protein (Myc Tag, His Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
Myc Tag, His Tag
Activity
not tested
Cat no : Eg0185
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <0.1 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human FGFRL1 protein Ala25-Pro378 (Accession# Q8N441) with a Myc tag and a His tag at the C-terminus. |
| GeneID | 53834 |
| Accession | Q8N441 |
| PredictedSize | 43.9 kDa |
| SDS-PAGE | 60-75 kDa, reducing (R) conditions |
| Formulation | Lyophilized from 0.22 μm filtered solution in PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Fibroblast growth factor receptor-like 1 (FGFRL1) is a member of the FGFR family. It is a type I transmembrane protein which contains three extracellular Ig-like modules, a transmembrane segment, and a short intracellular tail with a peculiar histidine-rich motif. It lacks the intracellular protein tyrosine kinase domain required for signal transduction by transphosphorylation. FGFRL1 binds to FGF ligands and heparin with high affinity. It exerts a negative effect on cell proliferation, but a positive effect on cell adhesion and cell differentiation.
References:
1. M Wiedemann, et al. (2000) Genomics. 69(2):275-9. 2. Beat Trueb, et al. (2003) J Biol Chem. 278(36):33857-65. 3. Beat Trueb. (2011) Cell Mol Life Sci. 68(6):951-64. 4. Xiaochen Yang, et al. (2016) Int J Mol Med. 38(1):30-8.