Fibroblast growth factor 2 (FGF2) is one of the most well-studied members of the fibroblast growth factor superfamil. FGF2 can be synthesized and secreted by human adipocytes. FGF2 activates its target receptor tyrosine kinases, the FGFRs, on the cell surface in order to activate numerous downstream pathways, including several mitogen activated protein kinase (MAPK) pathways. FGF2 inhibited TGFβ-mediated fibroblast activation, resulting in more rapidly proliferating, spindle-shaped cells, compared to the more slowly proliferating, flatter TGFβ-treated cells. FGF2 is an important regulator of cell growth and differentiation under physiological and pathological conditions. FGF2 is widely involved in important biological processes such as stem cell proliferation and angiogenesis.