Recombinant Human CXCL5 protein (rFc Tag)
Species
Human
Purity
>90 %, SDS-PAGE
Tag
rFc Tag
Activity
not tested
Cat no : Eg2939
Validation Data Gallery
Product Information
| Purity | >90 %, SDS-PAGE |
| Endotoxin | <1.0 EU/μg protein, LAL method |
| Activity |
Not tested |
| Expression | HEK293-derived Human CXCL5 protein Ala37-Asn114 (Accession# P42830) with a rabbit IgG Fc tag at the C-terminus. |
| GeneID | 6374 |
| Accession | P42830 |
| PredictedSize | 34.0 kDa |
| SDS-PAGE | |
| Formulation | Lyophilized from sterile PBS, pH 7.4. Normally 5% trehalose and 5% mannitol are added as protectants before lyophilization. |
| Reconstitution | Briefly centrifuge the tube before opening. Reconstitute at 0.1-0.5 mg/mL in sterile water. |
| Storage Conditions |
It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
|
| Shipping | The product is shipped at ambient temperature. Upon receipt, store it immediately at the recommended temperature. |
Background
Chemokines are a class of pro-inflammatory cytokines that can recruit and activate chemotactic cells. C‐X‐C motif chemokine ligand 5 (CXCL5) is a member of the chemokine family binding CXCR2 (C-X-C Motif Chemokine Receptor 2), a G-protein coupled receptor. CXCL5 is an inflammatory mediator and a powerful attractant for granulocytic immune cells. CXCL5 is a chemokine that promotes tumor formation by triggering the migration of immune cells to tumors and promotes immmuno-suppressive characteristics of the tumor microenvironment. In addition, CXCL5 can also promote tumor cell metastasis and recruit vascular endothelial cells for angiogenesis.
References:
1. Deng, Jie et al. Frontiers in oncology vol. 12 (2022): 944494. 2. Kawamura, Mikio et al. European journal of cancer (Oxford, England : 1990) vol. 48,14 (2012): 2244-51. 3. Hu, Binwu et al. Cancer cell international vol. 18 (2018): 68. 4. Begley, Lesa A et al. Neoplasia (New York, N.Y.) vol. 10,3 (2008): 244-54. 5. Koltsova, Ekaterina K, and Klaus Ley. Immunity vol. 33,1 (2010): 7-9.